Genetic deletion or pharmacological inhibition of acetyl-CoA carboxylase 2 enhances fatty acid oxidation and improves cardiac function and survival in the murine ATGL knockout model of severe heart failure

Genetic deletion or pharmacological inhibition of acetyl-CoA carboxylase 2 enhances fatty acid oxidation and improves cardiac function and survival in the murine ATGL knockout model of severe heart failure

Impaired myocardial energetics, including fatty acid oxidation (FAO), is a hallmark feature in the pathophysiology of various disorders. Deficiency of adipose triglyceride lipase (ATGL) results in impaired FAO which leads to severe heart failure due to massive triglyceride accumulation in cardiac mu...

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Bibliographic Details
Main Authors: Mai Usui, Yu Tsurekawa, Tatsuya Ikehara, Atsuyuki Shimazaki, Archana Vijayakumar, Robert P. Myers, G. Mani Subramanian, Eisuke Murakami
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Journal of Molecular and Cellular Cardiology Plus
Subjects:
Cardiovascular therapeutics
Cardiac metabolism
Triglycerides
Fatty acid oxidation
ACC2
Online Access:http://www.sciencedirect.com/science/article/pii/S2772976125001783
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