Glyoxalase-1 overexpression attenuates arterial wall stiffening in diabetic mice

Glyoxalase-1 overexpression attenuates arterial wall stiffening in diabetic mice

Abstract Aims Diabetes is a leading cause of mortality worldwide, primarily due to cardiovascular diseases (CVD). Arterial stiffness is a CVD predictor and is associated with increased mortality in diabetic individuals. In diabetes, the formation and accumulation of methylglyoxal (MGO), a highly rea...

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Main Authors: Margarita G. Pencheva, Eline Berends, Koen W. F. van der Laan, Alessandro Giudici, Petra Niessen, Jean L. J. M. Scheijen, Philippe Vangrieken, Peter Leenders, Tammo Delhaas, Florian Caiment, Martina Kutmon, Fabiola M. Trujillo, Kristiaan Wouters, Sébastien Foulquier, Bart Spronck, Koen D. Reesink, Casper G. Schalkwijk
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cardiovascular Diabetology
Online Access:https://doi.org/10.1186/s12933-025-02823-4
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https://doi.org/10.1186/s12933-025-02823-4

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