Neuroprotective effects of saikosaponin-A in ethanol-induced glia-mediated neuroinflammation, oxidative stress via RAGE/TLR4/NFkB signaling

Neuroprotective effects of saikosaponin-A in ethanol-induced glia-mediated neuroinflammation, oxidative stress via RAGE/TLR4/NFkB signaling

Chronic use of ethanol leads to psychological and physiological dependence followed by neurodegeneration via glia-mediated neuroinflammation, and oxidative stress. The current study is aimed at the neuroprotective effects of saikosaponin-A against ethanol-induced neurodegeneration. Here, saikosaponi...

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Bibliographic Details
Main Authors: Waqar Ali, Kyonghwan Choe, Min Hwa Kang, Jawad Ali, Hyun Young Park, Abubakar Atiq, Sareer Ahmad, Tae Ju Park, Myeong Ok Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
alcohol
neurodegeneration
gliosis
oxidative stress
saikosaponin-A
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2025.1625362/full
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https://www.frontiersin.org/articles/10.3389/fncel.2025.1625362/full

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