Cathepsin-K Targeted by Sanggenol L Induces Lethal Autophagy through ROS-Dependent AMPK/mTOR Signaling in Gastric Cancer

Cathepsin-K Targeted by Sanggenol L Induces Lethal Autophagy through ROS-Dependent AMPK/mTOR Signaling in Gastric Cancer

Introduction: Sanggenol L (Sang gen chun L) is a bioactive flavonoid derived from Morus alba (Sang bai pi), a traditional Chinese medicine widely used for clearing lung heat, promoting blood circulation, and reducing inflammation. Gastric cancer (GC) remains one of the most lethal malignancies world...

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Bibliographic Details
Main Authors: Kui Zhang, Xin Hu, Jingjing Su, Guangzhao Pan, Abhimanyu Thakur, Natalia Baran, Anne Dijkstra, Isha Gaurav, Zhijun Yang, Hongjuan Cui
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Pharmacological Research - Modern Chinese Medicine
Subjects:
abbreviations: cTSK, Cathepsin K
ROS, Reactive Oxygen Species
AMPK, AMP-activated Protein Kinase
GC, Gastric Cancer
PERK, Protein Kinase RNA-like Endoplasmic Reticulum Kinase
elF2α, Eukaryotic Translation Initiation Factor 2 Subunit Alpha
Online Access:http://www.sciencedirect.com/science/article/pii/S2667142525000405
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