hESCs‐derived Organoids Achieve Liver Zonation Features through LSEC Modulation

hESCs‐derived Organoids Achieve Liver Zonation Features through LSEC Modulation

Abstract Liver zonation, essential for diverse physiological functions, is lacking in existing organoid models, hindering their ability to recapitulate liver development and pathogenesis. Addressing this gap, this work explores the feasibility of achieving zonated organoid by co‐culturing human embr...

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Bibliographic Details
Main Authors: Yuying Zhang, Chenyan Huang, Lei Sun, Lyu Zhou, Yudi Niu, Kaini Liang, Bingjie Wu, Peng Zhao, Zhiqiang Liu, Xiaolin Zhou, Peng Zhang, Jianchen Wu, Jie Na, Yanan Du
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Advanced Science
Subjects:
GLP‐1R
hESCs‐derived LSEC
liver zonation
MAFLD
PEGMA‐grafted PDMS microwell chip
zonated organoids
Online Access:https://doi.org/10.1002/advs.202411667
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https://doi.org/10.1002/advs.202411667

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