Pan-cancer analysis of CHRDL1 expression and its mechanistic role in inhibiting EMT via the TGF-β pathway in lung adenocarcinoma

Pan-cancer analysis of CHRDL1 expression and its mechanistic role in inhibiting EMT via the TGF-β pathway in lung adenocarcinoma

BackgroundThe primary objective of this study is to conduct a pan-cancer analysis of CHRDL1 expression, to determine its correlation with patient survival rates, immune cell infiltration, and drug sensitivity. Additionally, the study aimed to further validate the mechanistic role of CHRDL1 in lung a...

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Bibliographic Details
Main Authors: Honghong Dong, Yahui Tian, Shaowei Xin, Yujie Guo, Suxin Jiang, Zitong Wan, Huaiyu Wang, Yong Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Chrdl1
lung adenocarcinoma
pan-cancer analysis
Epithelialmesenchymal transition
TGF-β pathway
immune infiltration
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1557761/full
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https://www.frontiersin.org/articles/10.3389/fcell.2025.1557761/full

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