3D Coaxial Printing of Small‐Diameter Artificial Arteries
As a treatment for the widely spread cardiovascular diseases (CVD), bypass vascular grafts have room for improvement in terms of mechanical property match with native arteries. A 3D‐printed nozzle is presented, featuring unique internal structures, to extrude artificial vascular grafts with a flower...
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Wiley-VCH
2025-02-01
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| Series: | Small Structures |
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| Online Access: | https://doi.org/10.1002/sstr.202400323 |
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| author | Yuxiang Zhu Siying Liu Xuan Mei Zeng Lin Tiffany V. Pulido Jixin Hou Srikar Anudeep Remani Dhanush Patil Martin Taylor Sobczak Arunachalam Ramanathan Sri Vaishnavi Thummalapalli Lindsay B. Chambers Churan Yu Shenghan Guo Yiping Zhao Yang Liu Xianqiao Wang Jessica N. Lancaster Yu Shrike Zhang Xiangfan Chen Kenan Song |
| author_facet | Yuxiang Zhu Siying Liu Xuan Mei Zeng Lin Tiffany V. Pulido Jixin Hou Srikar Anudeep Remani Dhanush Patil Martin Taylor Sobczak Arunachalam Ramanathan Sri Vaishnavi Thummalapalli Lindsay B. Chambers Churan Yu Shenghan Guo Yiping Zhao Yang Liu Xianqiao Wang Jessica N. Lancaster Yu Shrike Zhang Xiangfan Chen Kenan Song |
| author_sort | Yuxiang Zhu |
| collection | DOAJ |
| description | As a treatment for the widely spread cardiovascular diseases (CVD), bypass vascular grafts have room for improvement in terms of mechanical property match with native arteries. A 3D‐printed nozzle is presented, featuring unique internal structures, to extrude artificial vascular grafts with a flower‐mimicking geometry. The multilayer‐structured graft wall allows the inner and outer layers to interfere sequentially during lateral expansion, replicating the nonlinear elasticity of native vessels. Both experiment and simulation results verify the necessity and benefit of the flower‐mimicking structure in obtaining the self‐toughening behavior. The gelation study of natural polymers and the utilization of sacrificial phase enables the smooth extrusion of the multiphase conduit, where computer‐assisted image analysis is employed to quantify manufacturing fidelity. The cell viability tests demonstrate the cytocompatibility of the gelatin methacryloyl (GelMA)/sodium alginate grafts, suggesting potential for further clinical research with further developments. This study presents a feasible approach for fabricating bypass vascular grafts and inspires future treatments for CVD. |
| format | Article |
| id | doaj-art-421c149262654157a61f7b0a3cda3f14 |
| institution | Kabale University |
| issn | 2688-4062 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Small Structures |
| spelling | doaj-art-421c149262654157a61f7b0a3cda3f142025-02-04T08:10:21ZengWiley-VCHSmall Structures2688-40622025-02-0162n/an/a10.1002/sstr.2024003233D Coaxial Printing of Small‐Diameter Artificial ArteriesYuxiang Zhu0Siying Liu1Xuan Mei2Zeng Lin3Tiffany V. Pulido4Jixin Hou5Srikar Anudeep Remani6Dhanush Patil7Martin Taylor Sobczak8Arunachalam Ramanathan9Sri Vaishnavi Thummalapalli10Lindsay B. Chambers11Churan Yu12Shenghan Guo13Yiping Zhao14Yang Liu15Xianqiao Wang16Jessica N. Lancaster17Yu Shrike Zhang18Xiangfan Chen19Kenan Song20Manufacturing Engineering School of Manufacturing Systems and Networks (MSN) Ira A. Fulton Schools Arizona State University Mesa AZ 85212 USASchool of Manufacturing Systems and Networks (MSN) Arizona State University Mesa AZ 85212 USADivision of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge MA 02139 USADivision of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge MA 02139 USADepartment of Immunology Mayo Clinic Arizona 13400 E Shea Blvd Scottsdale AZ 85259 USASchool of Environmental, Civil, Agricultural, and Mechanical Engineering (ECAM) College of Engineering University of Georgia Athens GA 30602 USAManufacturing Engineering School of Manufacturing Systems and Networks (MSN) Ira A. Fulton Schools Arizona State University Mesa AZ 85212 USASchool of Environmental, Civil, Agricultural, and Mechanical Engineering (ECAM) College of Engineering University of Georgia Athens GA 30602 USASchool of Environmental, Civil, Agricultural, and Mechanical Engineering (ECAM) College of Engineering University of Georgia Athens GA 30602 USASchool of Environmental, Civil, Agricultural, and Mechanical Engineering (ECAM) College of Engineering University of Georgia Athens GA 30602 USASchool of Environmental, Civil, Agricultural, and Mechanical Engineering (ECAM) College of Engineering University of Georgia Athens GA 30602 USASchool of Environmental, Civil, Agricultural, and Mechanical Engineering (ECAM) College of Engineering University of Georgia Athens GA 30602 USASchool of Environmental, Civil, Agricultural, and Mechanical Engineering (ECAM) College of Engineering University of Georgia Athens GA 30602 USAManufacturing Engineering School of Manufacturing Systems and Networks (MSN) Ira A. Fulton Schools Arizona State University Mesa AZ 85212 USADepartment of Physics and Astronomy Adjunct Professor College of Engineering University of Georgia Athens GA 30602 USASchool of Chemical, Material & Biomedical Engineering (CMBE) College of Engineering University of Georgia Athens GA 30602 USASchool of Environmental, Civil, Agricultural, and Mechanical Engineering (ECAM) College of Engineering University of Georgia Athens GA 30602 USADepartment of Immunology Mayo Clinic Arizona 13400 E Shea Blvd Scottsdale AZ 85259 USADivision of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge MA 02139 USAManufacturing Engineering School of Manufacturing Systems and Networks (MSN) Ira A. Fulton Schools Arizona State University Mesa AZ 85212 USASchool of Environmental, Civil, Agricultural, and Mechanical Engineering (ECAM) College of Engineering University of Georgia Athens GA 30602 USAAs a treatment for the widely spread cardiovascular diseases (CVD), bypass vascular grafts have room for improvement in terms of mechanical property match with native arteries. A 3D‐printed nozzle is presented, featuring unique internal structures, to extrude artificial vascular grafts with a flower‐mimicking geometry. The multilayer‐structured graft wall allows the inner and outer layers to interfere sequentially during lateral expansion, replicating the nonlinear elasticity of native vessels. Both experiment and simulation results verify the necessity and benefit of the flower‐mimicking structure in obtaining the self‐toughening behavior. The gelation study of natural polymers and the utilization of sacrificial phase enables the smooth extrusion of the multiphase conduit, where computer‐assisted image analysis is employed to quantify manufacturing fidelity. The cell viability tests demonstrate the cytocompatibility of the gelatin methacryloyl (GelMA)/sodium alginate grafts, suggesting potential for further clinical research with further developments. This study presents a feasible approach for fabricating bypass vascular grafts and inspires future treatments for CVD.https://doi.org/10.1002/sstr.2024003233D printingbiomaterialscardiovascular diseasescoaxial extrusionsnonlinear elasticities |
| spellingShingle | Yuxiang Zhu Siying Liu Xuan Mei Zeng Lin Tiffany V. Pulido Jixin Hou Srikar Anudeep Remani Dhanush Patil Martin Taylor Sobczak Arunachalam Ramanathan Sri Vaishnavi Thummalapalli Lindsay B. Chambers Churan Yu Shenghan Guo Yiping Zhao Yang Liu Xianqiao Wang Jessica N. Lancaster Yu Shrike Zhang Xiangfan Chen Kenan Song 3D Coaxial Printing of Small‐Diameter Artificial Arteries Small Structures 3D printing biomaterials cardiovascular diseases coaxial extrusions nonlinear elasticities |
| title | 3D Coaxial Printing of Small‐Diameter Artificial Arteries |
| title_full | 3D Coaxial Printing of Small‐Diameter Artificial Arteries |
| title_fullStr | 3D Coaxial Printing of Small‐Diameter Artificial Arteries |
| title_full_unstemmed | 3D Coaxial Printing of Small‐Diameter Artificial Arteries |
| title_short | 3D Coaxial Printing of Small‐Diameter Artificial Arteries |
| title_sort | 3d coaxial printing of small diameter artificial arteries |
| topic | 3D printing biomaterials cardiovascular diseases coaxial extrusions nonlinear elasticities |
| url | https://doi.org/10.1002/sstr.202400323 |
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