Hepatitis B virus-infected hepatocytes promote the secretion of collagen VI to the extracellular matrix

Hepatitis B virus-infected hepatocytes promote the secretion of collagen VI to the extracellular matrix

Abstract Chronic hepatitis B virus (HBV) infection is a global health problem as it is the major cause of liver fibrosis and its complications cirrhosis and hepatocellular carcinoma. The role of virus–host interactions in liver fibrosis and progression to cancer remains poorly understood. Here we sh...

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Main Authors: Alessia Virzì, Zakaria Boulahtouf, Julien Moehlin, Lea Girard, Laura Meiss-Heydmann, Charlotte Bach, Emma Gerges, Sarah C. Durand, Marine A. Oudot, Armando A. Roca Suarez, Oliver Popp, Evelyn Ramberger, Philipp Mertins, Emanuele Felli, Patrick Pessaux, Catherine Schuster, Eloi R. Verrier, Thomas F. Baumert, Joachim Lupberger
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Liver
Fibrosis
AKT signaling
Proteomics
Extracellular matrix
Online Access:https://doi.org/10.1038/s41598-025-09870-7
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https://doi.org/10.1038/s41598-025-09870-7

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