Critical gene network and signaling pathway analysis of the extracellular signal-regulated kinase (ERK) pathway in ischemic stroke

Critical gene network and signaling pathway analysis of the extracellular signal-regulated kinase (ERK) pathway in ischemic stroke

Background and objectiveIschemic stroke remains a leading cause of morbidity worldwide, demanding reliable biomarkers and mechanistic insights to inform personalized diagnostic and therapeutic strategies. We sought to integrate multiple ischemic stroke transcriptomic datasets, identify key extracell...

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Bibliographic Details
Main Authors: Rui Mao, Lei Wang, Haitao Zhang, Jiaojiao Gong, Hua Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
ischemic stroke
ERK pathway
GADD45
DUSP1
machine learning
nomogram
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2025.1604670/full
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https://www.frontiersin.org/articles/10.3389/fnmol.2025.1604670/full

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