Integrative UHPLC-HRMS and computational biology reveal ferroptosis and anoikis targeting by Wenpitongluo decoction in cardiorenal syndrome

BackgroundThe Wenpitongluo Decoction (WPTLD) was a classical herbal formula composed of medicinal herbs with both edible and therapeutic properties. It demonstrated clinical efficacy in treating Cardiorenal Syndrome (CRS), though its mechanism of action remained unclear. Although inflammatory and ox...

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Bibliographic Details
Main Authors: Xinxin Mao, Shuqing Shi, Chunmei Chen, Yumeng Li, Bingxuan Zhang, Qingqiao Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Chemistry
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Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2025.1617676/full
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