Reduced Levels of miR-145-3p Drive Cell Cycle Progression in Advanced High-Grade Serous Ovarian Cancer

Reduced Levels of miR-145-3p Drive Cell Cycle Progression in Advanced High-Grade Serous Ovarian Cancer

High-grade serous ovarian cancer (HGSOC) is the most lethal form of gynecologic cancer, with limited treatment options and a poor prognosis. Epigenetic factors, such as microRNAs (miRNAs) and DNA methylation, play pivotal roles in cancer progression, yet their specific contributions to HGSOC remain...

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Main Authors: Eva González-Cantó, Mariana Monteiro, Cristina Aghababyan, Ana Ferrero-Micó, Sergio Navarro-Serna, Maravillas Mellado-López, Sarai Tomás-Pérez, Juan Sandoval, Antoni Llueca, Alejandro Herreros-Pomares, Juan Gilabert-Estellés, Vicente Pérez-García, Josep Marí-Alexandre
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Cells
Subjects:
high-grade serous ovarian cancer
miRNAs
DNA methylation
miR-145-3p
cell cycle proliferation
cyclin D1-CDK4/6 pathway
Online Access:https://www.mdpi.com/2073-4409/13/22/1904
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https://www.mdpi.com/2073-4409/13/22/1904

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