Pancreatic islet β-cell subtypes are derived from biochemically-distinct and nutritionally-regulated islet progenitors

Pancreatic islet β-cell subtypes are derived from biochemically-distinct and nutritionally-regulated islet progenitors

Abstract Endocrine islet β cells comprise heterogenous subtypes with different gene expression and function levels. Here we study when/how this heterogeneity is induced and how long each subtype maintains its characteristic properties. We show that islet progenitors with distinct gene expression and...

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Main Authors: Monica E. Brown, Verda E. Miranda, Simone Nevills, Ruiying Hu, Prasanna K. Dadi, Alan J. Simmons, Yanwen Xu, Yilin Yang, Mahircan Yagan, Sadia Najam, Leesa L. Sampson, Mark A. Magnuson, David A. Jacobson, Ken S. Lau, Emily Hodges, Guoqiang Gu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60831-0
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https://doi.org/10.1038/s41467-025-60831-0

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