Recent advances in the anti-tumor activities of saponins through cholesterol regulation
Abnormal cholesterol metabolism has become a popular therapeutic target in cancer therapy. In recent years there has been a surge in interest in the anti-tumor activities of saponins, particularly their ability to disrupt cholesterol homeostasis in tumor cells. Cholesterol regulation by saponins is...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1469392/full |
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| author | Min Jiang Chao Hong Chao Hong Wenkui Zou Zheng Ye Lu Lu Lu Lu Yun Liu Yun Liu Tong Zhang Tong Zhang Yue Ding Yue Ding Yue Ding |
| author_facet | Min Jiang Chao Hong Chao Hong Wenkui Zou Zheng Ye Lu Lu Lu Lu Yun Liu Yun Liu Tong Zhang Tong Zhang Yue Ding Yue Ding Yue Ding |
| author_sort | Min Jiang |
| collection | DOAJ |
| description | Abnormal cholesterol metabolism has become a popular therapeutic target in cancer therapy. In recent years there has been a surge in interest in the anti-tumor activities of saponins, particularly their ability to disrupt cholesterol homeostasis in tumor cells. Cholesterol regulation by saponins is a complex process that involves multiple mechanisms. However, there are now a notable dearth of comprehensive reviews addressing their anti-tumor effects through cholesterol modulation. This review will explore the intricate mechanisms by which saponins regulate cholesterol, including modulation of synthesis, metabolism, and uptake, as well as complex formation with cholesterol. It will also outline how saponins exert their anti-cancer activities through cholesterol regulation, enhancing cytotoxicity, inhibiting tumor cell metastasis, reversing drug resistance, inducing immunotoxin macromolecule escape, and ferroptosis. This comprehensive analysis offers insights into the potential for the use of saponins anti-tumor therapies and their combinations with other drugs, advancing the understanding of their effects on cancer cells. |
| format | Article |
| id | doaj-art-41c587f1a4194e08803172a0fd1c20eb |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-41c587f1a4194e08803172a0fd1c20eb2025-01-07T06:40:45ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.14693921469392Recent advances in the anti-tumor activities of saponins through cholesterol regulationMin Jiang0Chao Hong1Chao Hong2Wenkui Zou3Zheng Ye4Lu Lu5Lu Lu6Yun Liu7Yun Liu8Tong Zhang9Tong Zhang10Yue Ding11Yue Ding12Yue Ding13School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaState Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaState Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaState Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaState Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaState Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaNational Innovation Platform for Medical Industry-Education Integration, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaAbnormal cholesterol metabolism has become a popular therapeutic target in cancer therapy. In recent years there has been a surge in interest in the anti-tumor activities of saponins, particularly their ability to disrupt cholesterol homeostasis in tumor cells. Cholesterol regulation by saponins is a complex process that involves multiple mechanisms. However, there are now a notable dearth of comprehensive reviews addressing their anti-tumor effects through cholesterol modulation. This review will explore the intricate mechanisms by which saponins regulate cholesterol, including modulation of synthesis, metabolism, and uptake, as well as complex formation with cholesterol. It will also outline how saponins exert their anti-cancer activities through cholesterol regulation, enhancing cytotoxicity, inhibiting tumor cell metastasis, reversing drug resistance, inducing immunotoxin macromolecule escape, and ferroptosis. This comprehensive analysis offers insights into the potential for the use of saponins anti-tumor therapies and their combinations with other drugs, advancing the understanding of their effects on cancer cells.https://www.frontiersin.org/articles/10.3389/fphar.2024.1469392/fullsaponinsanti-tumorcell membranecholesterolmetabolism |
| spellingShingle | Min Jiang Chao Hong Chao Hong Wenkui Zou Zheng Ye Lu Lu Lu Lu Yun Liu Yun Liu Tong Zhang Tong Zhang Yue Ding Yue Ding Yue Ding Recent advances in the anti-tumor activities of saponins through cholesterol regulation Frontiers in Pharmacology saponins anti-tumor cell membrane cholesterol metabolism |
| title | Recent advances in the anti-tumor activities of saponins through cholesterol regulation |
| title_full | Recent advances in the anti-tumor activities of saponins through cholesterol regulation |
| title_fullStr | Recent advances in the anti-tumor activities of saponins through cholesterol regulation |
| title_full_unstemmed | Recent advances in the anti-tumor activities of saponins through cholesterol regulation |
| title_short | Recent advances in the anti-tumor activities of saponins through cholesterol regulation |
| title_sort | recent advances in the anti tumor activities of saponins through cholesterol regulation |
| topic | saponins anti-tumor cell membrane cholesterol metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1469392/full |
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