Characterization of a non-nudix pyrophosphatase points to interplay between flavin and NAD(H) homeostasis in Saccharomyces cerevisiae.

Characterization of a non-nudix pyrophosphatase points to interplay between flavin and NAD(H) homeostasis in Saccharomyces cerevisiae.

The flavin cofactors FMN and FAD are required for a wide variety of biological processes, however, little is known about their metabolism. Here, we report the cloning and biochemical characterization of the Saccharomyces cerevisiae pyrophosphatase Fpy1p. Genetic and functional studies suggest that F...

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Main Authors: Joseph H Lynch, Na Sa, Sompop Saeheng, Nadia Raffaelli, Sanja Roje
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0198787/1/pone.0198787.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210218%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210218T092536Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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