Narirutin treatment accelerates the process of diabetic wound repair by regulating phenotype switching of macrophages through affecting metabolic reprogramming

Narirutin treatment accelerates the process of diabetic wound repair by regulating phenotype switching of macrophages through affecting metabolic reprogramming

IntroductionDiabetic foot ulcer (DFU) is one of the most common complications of diabetes, with substantial morbidity and mortality. Narirutin (Nar), a bioactive phytochemical derived from citrus peel, has been suggested to possess anti-inflammatory abilities. However, the involvement of Nar in DFU...

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Bibliographic Details
Main Authors: Liang Liu, Han Wang, Juan Zhou, Jing Lu, Yan Zhang, Haiyan Liu, Li Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
diabetic foot ulcer
narirutin
macrophage
metabolic reprogramming
AMPK
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1614967/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1614967/full

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