Targeting the ANXA8–SP1–PPA1 Axis to Modulate TCA Cycle and Matrix Deposition in Diffuse-Type Gastric Cancer

Targeting the ANXA8–SP1–PPA1 Axis to Modulate TCA Cycle and Matrix Deposition in Diffuse-Type Gastric Cancer

Diffuse-type gastric cancer (DGC) is an aggressive tumor type characterized by a dense extracellular matrix (ECM). Metabolic reprogramming, a key oncogenic factor driving tumor progression, is closely linked to ECM deposition, although the regulatory mechanisms remain poorly understood. In this stud...

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Main Authors: Yuxia Wu, Xiangyan Jiang, Huiguo Qing, Yansong Hou, Yong Ma, Tao Wang, Keshen Wang, Long Qin, Weiwen Cai, Zongrui Xing, Bin Zhao, Qichen He, Wenbo Liu, Tian Wang, Haonan Sun, Xingshuo Zhao, Zuoyi Jiao, Zeyuan Yu
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2025-01-01
Series:Research
Online Access:https://spj.science.org/doi/10.34133/research.0838
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https://spj.science.org/doi/10.34133/research.0838

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