Dual treatment with Val-083 and AZD1775 shows potent anti-tumor activity in diffuse midline glioma models

Dual treatment with Val-083 and AZD1775 shows potent anti-tumor activity in diffuse midline glioma models

Abstract H3K27M diffuse midline gliomas (DMG) are characterized by p53 mutations and hypomethylation of MGMT, a DNA-repair enzyme, leading to resistance towards chemotherapeutic agents such as temozolomide (TMZ). As an alternative, we investigated the efficacy of a functionally different DNA-damagin...

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Main Authors: Bavani Subramaniam, Debasish Roy, Ayda Woldegerima, Wai Chin Chong, Justyna M. Przystal, Jie Zhang, Sandra Laternser, Bettina Kritzer, Suraj Rangnath, Truman Knowles, Sridevi Yadavilli, Roger Packer, Sabine Mueller, Javad Nazarian
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-01006-4
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https://doi.org/10.1038/s41698-025-01006-4

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