Efficient Consecutive Synthesis of Fluorinated Isoflavone Analogs, X-Ray Structures, Hirshfeld Analysis, and Anticancer Activity Assessment

Efficient Consecutive Synthesis of Fluorinated Isoflavone Analogs, X-Ray Structures, Hirshfeld Analysis, and Anticancer Activity Assessment

The synthesis of 7-<i>O</i>-carboxymethyl-4′-fluoroisoflavone <b>4</b> and 7-<i>O</i>-carboxymethyl-4′-fluoro-2-trifluormethylisoflavone <b>7</b> involved the cyclization of 2,4-dihydroxy-4′-fluorodeoxybenzoin <b>1</b>, followed by 7-<i&...

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Bibliographic Details
Main Authors: Mohammed Salah Ayoup, Malak Daqa, Yousef Salama, Rand Hazzam, Mohammed B. Hawsawi, Saied M. Soliman, Nawaf Al-Maharik
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Molecules
Subjects:
4′-fluoroisflavones
7-<i>O</i>-carboxmethyl-4′-fluoroisoflavone
XRD crystallography
anticancer
MCF7 cancer cells
Online Access:https://www.mdpi.com/1420-3049/30/4/795
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