Protective Effects of Interleukin‐1 Inhibition With Anakinra in Mouse Models of Ischemic Stroke With and Without Reperfusion

Protective Effects of Interleukin‐1 Inhibition With Anakinra in Mouse Models of Ischemic Stroke With and Without Reperfusion

Background Severe brain ischemia is associated with life‐threatening edema and inflammation. Interleukin‐1 is a crucial mediator of inflammation, and its blockade showed benefits in experimental stroke. We studied anakinra, a modified recombinant human interleukin‐1 receptor antagonist, in mouse mod...

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Main Authors: Nerea Chaparro‐Cabanillas, Alicia Aliena‐Valero, Jordi Pedragosa, Leire Pedrosa, Milagros Honores, Mercè Rossinyol‐Boladeres, Juan B. Salom, Ángel Chamorro, Juan I. Arostegui, Xabier Urra, Carles Justicia, Anna M. Planas
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
anakinra
cytokines
edema
inflammation
ischemic stroke
malignant infarction
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.040474
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https://www.ahajournals.org/doi/10.1161/JAHA.124.040474

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