PASTA kinase signaling regulates peptidoglycan synthesis in Enterococcus faecalis by direct inhibition of UDP-N-acetylglucosamine 1-carboxyvinyl transferase activity

PASTA kinase signaling regulates peptidoglycan synthesis in Enterococcus faecalis by direct inhibition of UDP-N-acetylglucosamine 1-carboxyvinyl transferase activity

ABSTRACT Proper control of bacterial peptidoglycan (PG) synthesis is critical to balance growth, cell division, and stress responses with other energetic needs of the cell. The first committed step of the PG biosynthetic pathway is catalyzed by UDP-N-acetylglucosamine 1-carboxyvinyl transferases (UN...

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Bibliographic Details
Main Authors: Carly A. Mascari, Dušanka Djorić, Christopher J. Kristich
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mBio
Subjects:
Firmicutes
Enterococcus faecalis
peptidoglycan synthesis
PASTA kinase
Online Access:https://journals.asm.org/doi/10.1128/mbio.00593-25
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https://journals.asm.org/doi/10.1128/mbio.00593-25

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