Dimeric natural product panepocyclinol A inhibits STAT3 via di-covalent modification

Dimeric natural product panepocyclinol A inhibits STAT3 via di-covalent modification

Homo- or heterodimeric compounds that affect dimeric protein function through interaction between monomeric moieties and protein subunits can serve as valuable sources of potent and selective drug candidates. Here, we screened an in-house dimeric natural product collection, and panepocyclinol A (Pec...

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Bibliographic Details
Main Authors: Li Li, Yuezhou Wang, Yiqiu Wang, Xiaoyang Li, Qihong Deng, Fei Gao, Wenhua Lian, Yunzhan Li, Fu Gui, Yanling Wei, Su-Jie Zhu, Cai-Hong Yun, Lei Zhang, Zhiyu Hu, Qingyan Xu, Xiaobing Wu, Lanfen Chen, Dawang Zhou, Jianming Zhang, Fei Xia, Xianming Deng
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Signal transducer and activator of transcription 3
STAT3 inhibitor
Anaplastic large T cell lymphoma
Dimerization
Dimeric compounds
Natural product
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383524004015
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