Unlocking liver physiology: comprehensive pathway maps for mechanistic understanding

Unlocking liver physiology: comprehensive pathway maps for mechanistic understanding

AimsIn silico methods provide a resourceful toolbox for new approach methodologies (NAMs). They can revolutionize chemical safety assessment by offering more efficient and human-relevant alternatives to traditional animal testing. In this study, we introduce two Liver Physiological Maps (PMs); compr...

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Main Authors: Luiz Ladeira, Anouk Verhoeven, Jonas van Ertvelde, Jian Jiang, Alessio Gamba, Julen Sanz-Serrano, Tamara Vanhaecke, Harm J. Heusinkveld, Ramiro Jover, Mathieu Vinken, Liesbet Geris, Bernard Staumont
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Toxicology
Subjects:
physiological maps
toxicology
systems biology
hepatology
new approach methodologies
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2025.1619651/full
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https://www.frontiersin.org/articles/10.3389/ftox.2025.1619651/full

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