Impact of FcRn antagonism on vaccine-induced protective immune responses against viral challenge in COVID-19 and influenza mouse vaccination models

Impact of FcRn antagonism on vaccine-induced protective immune responses against viral challenge in COVID-19 and influenza mouse vaccination models

Antagonism of the neonatal Fc receptor through an engineered antibody Fc fragment, such as efgartigimod, results in a decrease in immunoglobulin G levels. This approach is being evaluated as a therapeutic strategy for the treatment of IgG-mediated autoimmune diseases. Our goal was to evaluate the im...

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Bibliographic Details
Main Authors: Prajakta Warang, Gagandeep Singh, Mahan Moshir, Ornella Binazon, Gabriel Laghlali, Lauren A. Chang, Heidi Wouters, Peter Vanhoenacker, Margo Notebaert, Nadia Elhemdaoui, Kateřina Augustynková, Sophie Steeland, Peter Ulrichts, Judith Baumeister, Michael Schotsaert
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
SARS-CoV-2
COVID-19
influenza
vaccination
immunity
efgartigimod
Online Access:https://www.tandfonline.com/doi/10.1080/21645515.2025.2470542
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https://www.tandfonline.com/doi/10.1080/21645515.2025.2470542

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