A Network Analysis Approach to Detect and Differentiate Usher Syndrome Types Using miRNA Expression Profiles: A Pilot Study

A Network Analysis Approach to Detect and Differentiate Usher Syndrome Types Using miRNA Expression Profiles: A Pilot Study

<b>Background:</b> Usher syndrome (USH) is a rare genetic disorder that affects both hearing and vision. It presents in three clinical types—USH1, USH2, and USH3—with varying onset, severity, and disease progression. Existing diagnostics primarily rely on genetic profiling to identify va...

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Bibliographic Details
Main Authors: Rama Krishna Thelagathoti, Wesley A. Tom, Chao Jiang, Dinesh S. Chandel, Gary Krzyzanowski, Appolinaire Olou, Rohan M. Fernando
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:BioMedInformatics
Subjects:
Usher syndrome
miRNA
network analysis
miRNA microarray
subtype differentiation
feature selection
Online Access:https://www.mdpi.com/2673-7426/4/4/122
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