A secreted helminth microRNA suppresses gastrointestinal cell differentiation required for innate immunity

A secreted helminth microRNA suppresses gastrointestinal cell differentiation required for innate immunity

Pathogens have developed multiple strategies to modulate host immune defense mechanisms. Understanding how this is achieved has potential to inform novel therapeutics for diseases caused by immune dysfunction. Parasitic helminths are masters of immune evasion, via release of secreted products, resul...

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Bibliographic Details
Main Authors: Matias G. Perez, Victoria Gillan, William M. Anderson, François Gerbe, Fabien Herbert, Tom N. McNeilly, Rick M. Maizels, Philippe Jay, Eileen Devaney, Collette Britton
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
nematode parasites
microRNAs
stem cells
tuft cells
organoids
innate immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1558132/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1558132/full

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