Whole exome sequencing and polygenic risk assessment for kidney functions and clinical management in both hospital-based cohort and population-based Asian cohorts

Whole exome sequencing and polygenic risk assessment for kidney functions and clinical management in both hospital-based cohort and population-based Asian cohorts

Abstract Background Taiwan has the highest prevalence of chronic kidney disease (CKD) and end-stage kidney disease (ESKD) globally, making them major public health concerns with significant morbidity, mortality, and healthcare burden. While genetic risk factors for kidney disease have been identifie...

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Main Authors: Min-Rou Lin, I-Wen Wu, Wan-Hsuan Chou, Yung-Feng Lin, Kuan-Yu Hung, Kaname Kojima, Kosuke Shido, Kengo Kinoshita, Wei-Chiao Chang, Mai-Szu Wu
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Biomedical Science
Subjects:
Chronic kidney disease
End-stage kidney disease
Rare variants
Whole-exome sequencing
Genetic susceptibility
Polygenic risk score
Online Access:https://doi.org/10.1186/s12929-025-01168-0
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https://doi.org/10.1186/s12929-025-01168-0

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