Optimising sample preparation to enhance contrast-to-noise ratio in X-ray phase contrast tomography white matter (WM) imaging of the central nervous system

Optimising sample preparation to enhance contrast-to-noise ratio in X-ray phase contrast tomography white matter (WM) imaging of the central nervous system

The choice of fixative is critical in X-ray phase-contrast tomography (XPCT) because it affects tissue preservation, contrast enhancement and compatibility with other imaging techniques. A careful selection and optimization of fixatives can lead to significant improvements in the quality and accurac...

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Bibliographic Details
Main Authors: Michela Fratini, Lorenzo Massimi, Francesco Brun, Darren Batey, Inna Bukreeva, Alberto Mittone, Alberto Bravin, Elena Longo, Giuliana Tromba, Federico Giove, Silvia Cipiccia, Alejandra Sierra
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Physics
Subjects:
white matter (WM)
central nervous system
xylene
X ray phase-contrast tomography
advanced imaging techniques
Online Access:https://www.frontiersin.org/articles/10.3389/fphy.2025.1479573/full
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https://www.frontiersin.org/articles/10.3389/fphy.2025.1479573/full

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