Cardiomyocyte-derived exosomes carrying miR-181a-5p facilitate heart-brain crosstalk and exacerbate methamphetamine dependence in rats

Cardiomyocyte-derived exosomes carrying miR-181a-5p facilitate heart-brain crosstalk and exacerbate methamphetamine dependence in rats

BackgroundMethamphetamine (MA) is one of the most harmful synthetic drugs, yet the mechanisms underlying its addiction and relapse remain incompletely understood. This study investigates how cardiomyocyte-derived exosomes carrying miRNAs facilitate heart-brain crosstalk and contribute to MA dependen...

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Bibliographic Details
Main Authors: Hancheng Li, Yongen Peng, Yangkai Wu, Yiling Chen, Jieyu Li, Yunbing He, Hongwu Wang, Chaohua Luo, Zhixian Mo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
methamphetamine dependence
cardiomyocyte-derived exosomes
conditioned place preference
heart-brain crosstalk
miR-181a-5p
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1541442/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1541442/full

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