Intramuscular DNA vaccine provides protection in non-human primate and mouse models of SARS-CoV-2

Intramuscular DNA vaccine provides protection in non-human primate and mouse models of SARS-CoV-2

Nucleic acid vaccine approaches have proven successful in the context of the SARS-CoV-2 pandemic, however challenges with delivery remain. Here we describe PlaCCine, a DNA-based vaccine platform that utilizes a device- and vector-free chemical delivery system. This system includes a DNA plasmid enco...

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Bibliographic Details
Main Authors: Subeena Sood, Ebony N. Gary, Majed Matar, Jessica Kim, Casey E. Hojecki, Bryce Warner, Robert Vendramelli, Thang Truong, Alanna Smith, Jennifer Rice, Jeff Sparks, Michael DeSalvo, John Henderson, Joseph A. Rogers, Ankur Sharma, Laurent Pessaint, Carlo A. Iavarone, Darwyn Kobasa, Jean D. Boyer, Stacy Lindborg, Khursheed Anwer
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
DNA
vaccine
primate
mice
immunology
plasmid
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1589584/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1589584/full

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