Analytical and clinical validation of a high accuracy fully automated digital immunoassay for plasma phospho-Tau 217 for clinical use in detecting amyloid pathology

Analytical and clinical validation of a high accuracy fully automated digital immunoassay for plasma phospho-Tau 217 for clinical use in detecting amyloid pathology

BackgroundWith the emergence of disease-modifying therapies for Alzheimer’s disease (AD), there is an urgent need for scalable, accurate, and well-validated blood test alternatives to positron emission topography (PET) and lumbar punctures for identifying amyloid pathology to facilitate identificati...

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Main Authors: David Wilson, Meenakshi Khare, Gallen Triana-Baltzer, Michele Wolfe, Patrick Sheehy, Karen Copeland, Lyndal Hesterberg, Ann-Jeanette Vasko, Wiesje M. van der Flier, Inge M. W. Verberk, Charlotte E. Teunissen, Mike Miller
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Neurology
Subjects:
Alzheimer’s disease
immunoassay
p-Tau 217
validation
amyloid
Simoa
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2025.1568971/full
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https://www.frontiersin.org/articles/10.3389/fneur.2025.1568971/full

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