Headache in a Child with Pseudohypoparathyroidism: An Alarming Symptom Not to Miss
Background. While the endocrine manifestations of pseudohypoparathyroidism are well known, less is known about the associated brain and spine abnormalities. These abnormalities may present with nonspecific symptoms in the paediatric population, and lack of awareness to these uncommon manifestations...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/8840082 |
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| author | Sarah Wing-yiu Poon Brian Hon-yin Chung Anita Man-ching Tsang Grace Wing-kit Poon |
| author_facet | Sarah Wing-yiu Poon Brian Hon-yin Chung Anita Man-ching Tsang Grace Wing-kit Poon |
| author_sort | Sarah Wing-yiu Poon |
| collection | DOAJ |
| description | Background. While the endocrine manifestations of pseudohypoparathyroidism are well known, less is known about the associated brain and spine abnormalities. These abnormalities may present with nonspecific symptoms in the paediatric population, and lack of awareness to these uncommon manifestations of the disease may result in a delay in necessary intervention. Case Presentation. We herein present a case of known pseudohypoparathyroidism type 1a who presented initially with minor head injury. She later developed progressive worsening headache, increased irritability, and vomiting. Repeated imaging showed hydrocephalus and Chiari malformation type 1 necessitating emergency craniectomy. Conclusion. Growth hormone deficiency, a common manifestation of pseudohypoparathyroidism type 1a, results in underdevelopment of the posterior cranial fossa and may account for the higher incidence of Chiari malformation in this group of patients. Other associated neurological features reported in pseudohypoparathyroidism type 1a include spinal stenosis, syringomyelia, and craniosynostosis. While less commonly seen, awareness to these associations is important in order to optimize the multidisciplinary care to this group of patients. |
| format | Article |
| id | doaj-art-411b8b3308cb41fa8dd6f5cd14444316 |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-411b8b3308cb41fa8dd6f5cd144443162025-02-03T01:28:07ZengWileyCase Reports in Endocrinology2090-65012090-651X2020-01-01202010.1155/2020/88400828840082Headache in a Child with Pseudohypoparathyroidism: An Alarming Symptom Not to MissSarah Wing-yiu Poon0Brian Hon-yin Chung1Anita Man-ching Tsang2Grace Wing-kit Poon3Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong KongDepartment of Paediatrics and Adolescent Medicine, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong KongDepartment of Paediatrics and Adolescent Medicine, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong KongDepartment of Paediatrics and Adolescent Medicine, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong KongBackground. While the endocrine manifestations of pseudohypoparathyroidism are well known, less is known about the associated brain and spine abnormalities. These abnormalities may present with nonspecific symptoms in the paediatric population, and lack of awareness to these uncommon manifestations of the disease may result in a delay in necessary intervention. Case Presentation. We herein present a case of known pseudohypoparathyroidism type 1a who presented initially with minor head injury. She later developed progressive worsening headache, increased irritability, and vomiting. Repeated imaging showed hydrocephalus and Chiari malformation type 1 necessitating emergency craniectomy. Conclusion. Growth hormone deficiency, a common manifestation of pseudohypoparathyroidism type 1a, results in underdevelopment of the posterior cranial fossa and may account for the higher incidence of Chiari malformation in this group of patients. Other associated neurological features reported in pseudohypoparathyroidism type 1a include spinal stenosis, syringomyelia, and craniosynostosis. While less commonly seen, awareness to these associations is important in order to optimize the multidisciplinary care to this group of patients.http://dx.doi.org/10.1155/2020/8840082 |
| spellingShingle | Sarah Wing-yiu Poon Brian Hon-yin Chung Anita Man-ching Tsang Grace Wing-kit Poon Headache in a Child with Pseudohypoparathyroidism: An Alarming Symptom Not to Miss Case Reports in Endocrinology |
| title | Headache in a Child with Pseudohypoparathyroidism: An Alarming Symptom Not to Miss |
| title_full | Headache in a Child with Pseudohypoparathyroidism: An Alarming Symptom Not to Miss |
| title_fullStr | Headache in a Child with Pseudohypoparathyroidism: An Alarming Symptom Not to Miss |
| title_full_unstemmed | Headache in a Child with Pseudohypoparathyroidism: An Alarming Symptom Not to Miss |
| title_short | Headache in a Child with Pseudohypoparathyroidism: An Alarming Symptom Not to Miss |
| title_sort | headache in a child with pseudohypoparathyroidism an alarming symptom not to miss |
| url | http://dx.doi.org/10.1155/2020/8840082 |
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