RNA synthesis in Leishmania donovani is constitutive during stage conversion: a genome-wide PRO-seq analysis

RNA synthesis in Leishmania donovani is constitutive during stage conversion: a genome-wide PRO-seq analysis

ABSTRACT Transcription in Leishmania donovani has long been considered constitutive, as shown by nuclear run-on analyses and northern blots, with gene expression primarily regulated post-transcriptionally. Using precision nuclear run-on sequencing (PRO-seq), we investigated active transcription in a...

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Bibliographic Details
Main Authors: Janne Grünebast, Stephan Lorenzen, Christine Brinker, Annika Bea, Joachim Clos
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:Microbiology Spectrum
Subjects:
nuclear run-on
polycistronic transcription
post-transcriptional regulation
gene expression
strand switch region
amastigote
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00566-25
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https://journals.asm.org/doi/10.1128/spectrum.00566-25

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