Prevalence of CCR7‐Positive CD8 T Cells as a Prognostic Factor in B‐Cell Maturation Antigen ‐Targeted Chimeric Antigen Receptor T Cell Therapy

Prevalence of CCR7‐Positive CD8 T Cells as a Prognostic Factor in B‐Cell Maturation Antigen ‐Targeted Chimeric Antigen Receptor T Cell Therapy

ABSTRACT Background Chimeric antigen receptor T (CAR‐T) cell therapy is effective for relapsed or refractory multiple myeloma (RRMM); however, relapse after the B‐cell maturation antigen (BCMA) CAR‐T cell therapy is associated with poor outcome. Hence, appropriate biomarkers that can predict the out...

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Main Authors: Yoshiaki Marumo, Masaki Ri, Toru Ebina, Tomoyuki Nakamura, Yoshiko Oshima, Takahiro Nakashima, Shiori Kinoshita, Tomotaka Suzuki, Tomoko Narita, Takaomi Sanda, Hirokazu Komatsu, Shinsuke Iida
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:eJHaem
Subjects:
BCMA‐targeting
CAR‐T cells
myeloma
T cell stemness
corresponding author: Masaki RI: rrmasaki.sub@gmail.com
Online Access:https://doi.org/10.1002/jha2.70040
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https://doi.org/10.1002/jha2.70040

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