Flavivirus NS4B proteins do not form homodimers: discrepancies with an AlphaFold-based oligomeric model

Flavivirus NS4B proteins do not form homodimers: discrepancies with an AlphaFold-based oligomeric model

In flaviviruses such as Dengue, Zika or West Nile virus (DENV, ZIKV or WNV), non-structural protein 4B (NS4B) participates in membrane remodeling during infection and is critical for virulence and host immunity. Despite the important roles and confirmed drug target status for NS4B, no detailed struc...

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Bibliographic Details
Main Authors: Wahyu Surya, Paula Tan, Shwe Sin Honey, Devanshu Mehta, Jaume Torres
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Flavivirus
Dengue
Zika
Non-structural protein 4B
Oligomerization
AlphaFold
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037025001497
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