Organelle stresses and energetic metabolisms promote endothelial–to–mesenchymal transition and fibrosis via upregulating FOSB and MEOX1 in Alzheimer’s disease

Organelle stresses and energetic metabolisms promote endothelial–to–mesenchymal transition and fibrosis via upregulating FOSB and MEOX1 in Alzheimer’s disease

IntroductionEndothelial-to-mesenchymal transition (EndoMT), cell death, and fibrosis are increasingly recognized as contributing factors to Alzheimer’s disease (AD) pathology, but the underlying transcriptomic mechanisms remain poorly defined. This study aims to elucidate transcriptomic changes asso...

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Main Authors: Fatma Saaoud, Mohammed Ben Issa, Lu Liu, Keman Xu, Yifan Lu, Ying Shao, Baosheng Han, Xiaohua Jiang, Xiaolei Liu, Avrum Gillespie, Jin Jun Luo, Laisel Martinez, Roberto Vazquez-Padron, Sadia Mohsin, Beata Kosmider, Hong Wang, Silvia Fossati, Xiaofeng Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Alzheimer’s disease
endothelial-to-mesenchymal transition (EndoMT)
fibrosis
endoplasmic reticulum (ER) stress
cellular stress
metabolic reprogramming
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2025.1605012/full
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https://www.frontiersin.org/articles/10.3389/fnmol.2025.1605012/full

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