Viral replication modulated by hallmark conformational ensembles: how AlphaFold-predicted features of RdRp folding dynamics combined with intrinsic disorder-mediated function enable RNA virus discovery

Viral replication modulated by hallmark conformational ensembles: how AlphaFold-predicted features of RdRp folding dynamics combined with intrinsic disorder-mediated function enable RNA virus discovery

The functions of RNA-dependent RNA polymerases (RdRps) in RNA viruses are demonstrably modulated by native substrates of dynamic and interconvertible conformational ensembles. Many of these are populated by essential flexible or intrinsically disordered regions (IDRs) that lack a stable three-dimens...

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Bibliographic Details
Main Authors: Rachid Tahzima, Justine Charon, Adrian Diaz, Kris De Jonghe, Sebastien Massart, Thierry Michon, Wim Vranken
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Virology
Subjects:
RNA-dependent RNA polymerase
RNA virus discovery
conformational ensembles
intrinsic disorder (IDP/IDR)
structural biology
AlphaFold2 (AF2)
Online Access:https://www.frontiersin.org/articles/10.3389/fviro.2025.1501616/full
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https://www.frontiersin.org/articles/10.3389/fviro.2025.1501616/full

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