Hybrid virtual screening and molecular dynamics approach for identification of allosteric modulator of EAAT2
EAAT2, a glial protein that clears excess glutamate from synapses, regulates synaptic transmission, and prevents excitotoxicity in neurons is impaired by Aβ induced oxidative stress in neurodegenerative diseases like Alzheimer’s disease. Therefore, compounds that enhance EAAT2 function by reducing o...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-10-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715624004624 |
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