Cryo-EM structures of the membrane repair protein dysferlin

Abstract Plasma membrane repair in response to damage is essential for cell viability. The ferlin family protein dysferlin plays a key role in Ca2+-dependent membrane repair in striated muscles. Mutations in dysferlin lead to a spectrum of diseases known as dysferlinopathies. The lack of a structure...

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Bibliographic Details
Main Authors: Hsiang-Ling Huang, Giovanna Grandinetti, Sarah M. Heissler, Krishna Chinthalapudi
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-53773-6
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