Enhanced cytotoxicity against cholangiocarcinoma by fifth-generation chimeric antigen receptor T cells targeting integrin αvβ6 and secreting anti-PD-L1 scFv

Enhanced cytotoxicity against cholangiocarcinoma by fifth-generation chimeric antigen receptor T cells targeting integrin αvβ6 and secreting anti-PD-L1 scFv

Abstract Cholangiocarcinoma (CCA) is a fatal bile duct cancer with high resistance and recurrence rates, with only one fifth of patients eligible for surgical treatment. The disease resists standard chemotherapy and often relapses. Chimeric antigen receptor (CAR) T cell therapy has shown promise for...

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Main Authors: Nattaporn Phanthaphol, Chalermchai Somboonpatarakun, Kwanpirom Suwanchiwasiri, Pornpimon Yuti, Jatuporn Sujjitjoon, Punn Augsornworawat, George S. Baillie, Mutita Junking, Pa-thai Yenchitsomanus
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Translational Medicine
Subjects:
Cholangiocarcinoma
Solid tumor immunotherapy
Chimeric antigen receptor T cells
Integrin αvβ6
PD-L1 blockade
3D spheroid model
Online Access:https://doi.org/10.1186/s12967-025-06453-y
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https://doi.org/10.1186/s12967-025-06453-y

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