Integration bile acid metabolomics and gut microbiome to study the anti-liver fibrosis effects of total alkaloids of Corydalis saxicola Bunting

Integration bile acid metabolomics and gut microbiome to study the anti-liver fibrosis effects of total alkaloids of Corydalis saxicola Bunting

Abstract Background Bile acids and gut microbiota participate in the pathogenesis of liver fibrosis (LF). The total alkaloids of Corydalis saxicola Bunting (TACS) is a traditional Chinese medicine extract that has been used to treat LF, but the underlying mechanisms are not clear. This study perform...

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Main Authors: Qianyi Wang, MeiLing Zhang, Mingwei Meng, Zhuo Luo, Ziping Pan, Lijun Deng, Jinghua Qin, Bingjian Guo, Dan Zhu, Yanmin Zhang, Hongwei Guo, Yonghong Liang, Zhiheng Su
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Chinese Medicine
Subjects:
Total alkaloids of Corydalis saxicola Bunting
Liver fibrosis
Bile acid
Gut microbiota
Fecal microbiota transplantation
Lactobacillus reuteri
Online Access:https://doi.org/10.1186/s13020-025-01158-2
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https://doi.org/10.1186/s13020-025-01158-2

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