A lentiviral vector targeting a KRAS neoepitope for cancer immunotherapy

A lentiviral vector targeting a KRAS neoepitope for cancer immunotherapy

Abstract Mutated oncogenic Kirsten rat sarcoma virus (KRAS) antigen is expressed in a large variety of cancers, including pancreatic, colorectal, and pulmonary cancers. The oncogenic KRAS mutations cause malignancies and are usually ubiquitously expressed by all cells of a tumor. The KRAS amino acid...

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Main Authors: Anastasia Goloudina, Fabien Le Chevalier, Pierre Authié, Sylvain Ciret, Kirill Nemirov, Ingrid Fert, Fanny Moncoq, Benjamin Vesin, Amandine Noirat, Catherine Blanc, Yu Wei, Pierre Charneau, Laleh Majlessi
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Cancer immunotherapy
Inhibition of tumor growth
KRAS oncogenic mutations
KRASG12D
Lentiviral vectors
Online Access:https://doi.org/10.1038/s41598-025-05134-6
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https://doi.org/10.1038/s41598-025-05134-6

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