TrypPROTACs Unlocking New Therapeutic Strategies for Chagas Disease

TrypPROTACs Unlocking New Therapeutic Strategies for Chagas Disease

Chagas disease, caused by the protozoan parasite <i>Trypanosoma cruzi</i> (<i>T. cruzi</i>), continues to pose significant public health challenges due to the toxicity, poor tolerability, and limited efficacy of current treatments. Targeted protein degradation (TPD) using pro...

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Bibliographic Details
Main Authors: Ana Luísa Rodriguez Gini, Pamela Souza Tada da Cunha, Emílio Emílio João, Chung Man Chin, Jean Leandro dos Santos, Esteban Carlos Serra, Cauê Benito Scarim
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pharmaceuticals
Subjects:
drug design
drug targeting
neglected tropical diseases
proteolysis targeting chimeras
<i>Trypanosoma cruzi</i> infection
ubiquitination
Online Access:https://www.mdpi.com/1424-8247/18/6/919
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