The dual role of TIGIT in regulatory and effector T cells in chronic liver disease

The dual role of TIGIT in regulatory and effector T cells in chronic liver disease

Background & Aims: Effective control of chronic liver diseases (CLD) requires suppression of effector T cells by CD4+CD25+CD127low regulatory T cells (Tregs). This study investigated the role of TIGIT, a co-inhibitory receptor, in CLD by examining the phenotype, recruitment, localisation, an...

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Main Authors: Amber G. Bozward, Scott P. Davies, Rémi Fiancette, Grace E. Wootton, Sian Faustini, Hin Fai Kwok, Naomi Richardson, Sean M. Morris, Kayani Kayani, Gary Middleton, Ye H. Oo
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:JHEP Reports
Subjects:
Checkpoint inhibitor
CTLA-4
IL-2
Immunotherapy
Autoimmune
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555925000825
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http://www.sciencedirect.com/science/article/pii/S2589555925000825

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