A novel molecular classification system for head and neck squamous cell carcinoma: predicting treatment response and metastatic potential through multi-omics analysis

A novel molecular classification system for head and neck squamous cell carcinoma: predicting treatment response and metastatic potential through multi-omics analysis

Abstract Background Head and neck squamous cell carcinoma (HNSCC) demonstrates significant heterogeneity, necessitating improved molecular classification for precision treatment. Methods We integrated single-cell and bulk RNA sequencing data from 59,376 cells across ten datasets using Scissor and sc...

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Bibliographic Details
Main Authors: XinYu Liu, YuJun Liu, XuTengYue Tian, Yue Xi, MiaoMiao Lu, Xin Zou, WanTao Chen
Format: Article
Language:English
Published: Springer 2025-04-01
Series:Discover Oncology
Subjects:
Head and neck squamous cell carcinoma
Molecular subtypes
RNA sequencing
Pan-cancer
Machine learning
Chemotherapy
Online Access:https://doi.org/10.1007/s12672-025-02257-0
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https://doi.org/10.1007/s12672-025-02257-0

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