Overexpression of BNIP3 in renal carcinoma cells can promote apoptosis of renal carcinoma cells through HIF-1α-BNIP3-mediated autophagy

Overexpression of BNIP3 in renal carcinoma cells can promote apoptosis of renal carcinoma cells through HIF-1α-BNIP3-mediated autophagy

BackgroundRenal cell carcinoma (RCC) is a prevalent malignancy with limited effective therapies, necessitating novel molecular targets. BNIP3, a pro-apoptotic protein regulated by hypoxia-inducible factor 1 (HIF-1), is implicated in autophagy and apoptosis, but its role in RCC under hypoxic conditio...

Full description

Saved in:
Bibliographic Details
Main Authors: Long Huang, Lin Wang, Dan Yuan, Yan Xu, Yu Wang, Kai Yao, Xiao Zhong, Quanda Liu, Kang Jia, Lei Lei, Haiyan Wang, Dongliang Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
Subjects:
renal cell carcinoma
BNIP3
B-cell lymphoma-2
HIF-1α
autophagy
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1614378/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2025.1614378/full

Similar Items