Intranasal delivery of a subunit protein vaccine provides protective immunity against JN.1 and XBB-lineage variants

Intranasal delivery of a subunit protein vaccine provides protective immunity against JN.1 and XBB-lineage variants

Abstract The mucosal immune response plays a crucial role in the prevention of respiratory viruses. Given the risk of recurrent SARS-CoV-2 infections in the population, the rapid development of next-generation intranasal COVID-19 vaccines with high safety and efficacy is paramount. In the current st...

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Main Authors: Hong Lei, Weiqi Hong, Jingyun Yang, Cai He, Yanan Zhou, Yu Zhang, Aqu Alu, Jie Shi, Jian Liu, Furong qin, Danyi Ao, Xiya Huang, Zimin Chen, Hao Yang, Yun Yang, Wenhai Yu, Cong Tang, Junbin Wang, Bai Li, Qing Huang, Hongbo Hu, Wei Cheng, Haohao Dong, Jian Lei, Lu Chen, Xikun Zhou, Jiong Li, Li Yang, Zhenling Wang, Wei Wang, Guobo Shen, Jinliang Yang, Zhiwei Zhao, Xiangrong Song, Guangwen Lu, Qiangming Sun, Youchun Wang, Shuaiyao Lu, Xiawei Wei
Format: Article
Language:English
Published: Nature Publishing Group 2024-11-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-024-02025-6
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https://doi.org/10.1038/s41392-024-02025-6

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