Contributions of major tau kinase activation and phospho-tau accumulation to cortical and hippocampal tangle formation and cognition in older adults

Contributions of major tau kinase activation and phospho-tau accumulation to cortical and hippocampal tangle formation and cognition in older adults

Aberrant activation of tau kinases (tauK) has been proposed as a major step in tau hyperphosphorylation and misfolding, and subsequent formation of neurofibrillary tangles (NFT) in Alzheimer's disease (AD). However, evidence of tauK hyperactivation in actual AD brains is scarce and inconsistent...

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Main Authors: Elena Hernández-Hernández, Vladislav A. Petyuk, Júlia Valor-Blanquer, Fernando Yáñez-Gómez, Alasdair M. Barr, Philip L. De Jager, Er-Yun Chen, Sue E. Leurgans, Julie A. Schneider, David A. Bennett, William G. Honer, M. Julia García-Fuster, Alfredo Ramos-Miguel
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Working memory
Human brain
Tau kinase
CDK-5
p25/p35
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125001408
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