The role and research progress of the MET signalling pathway in targeted therapy for osteosarcoma

The role and research progress of the MET signalling pathway in targeted therapy for osteosarcoma

MET, a receptor tyrosine kinase proto-oncogene and the specific receptor for hepatocyte growth factor (HGF), plays a critical role in the initiation and progression of osteosarcoma (OS) through sustained pathway activation. Aberrant activation of MET has been shown to trigger multiple downstream sig...

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Bibliographic Details
Main Authors: Qilong Su, Jingyu Hou, Xinhui Du, Fan Zhang, Panhong Zhang, Bangmin Wang, Weitao Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Oncology Reviews
Subjects:
osteosarcoma
MET signalling pathway
targeted therapy
small molecule inhibitors
specific antibody
combination therapy
Online Access:https://www.frontiersin.org/articles/10.3389/or.2025.1615111/full
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https://www.frontiersin.org/articles/10.3389/or.2025.1615111/full

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