IL13RA2-integrated genetically engineered mouse model allows for CAR T cells targeting pediatric high-grade gliomas

IL13RA2-integrated genetically engineered mouse model allows for CAR T cells targeting pediatric high-grade gliomas

Abstract Pediatric high-grade gliomas (pHGG) and pediatric diffuse midline gliomas (pDMG) are devastating diseases without durable and curative options. Although targeted immunotherapy has shown promise, the field lacks immunocompetent animal models to study these processes in detail. To achieve thi...

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Main Authors: M. Seblani, M. Zannikou, J. T. Duffy, T. Joshi, R. N. Levine, A. Thakur, M. Puigdelloses-Vallcorba, C. M. Horbinski, J. Miska, D. Hambardzumyan, O. J. Becher, Irina V. Balyasnikova
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Acta Neuropathologica Communications
Online Access:https://doi.org/10.1186/s40478-025-01991-4
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https://doi.org/10.1186/s40478-025-01991-4

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