SOX12 Facilitates Hepatocellular Carcinoma Progression and Metastasis through Promoting Regulatory T‐Cells Infiltration and Immunosuppression

SOX12 Facilitates Hepatocellular Carcinoma Progression and Metastasis through Promoting Regulatory T‐Cells Infiltration and Immunosuppression

Abstract Despite the success of immunotherapy in treating hepatocellular carcinoma (HCC), HCC remains a severe threat to health. Here, a crucial transcription factor, SOX12, is revealed that induces the immunosuppression of liver tumor microenvironment. Overexpressing SOX12 in HCC syngeneic models i...

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Main Authors: Xiangyuan Luo, Wenjie Huang, Siwen Li, Mengyu Sun, Dian Hu, Junqing Jiang, Zerui Zhang, Yijun Wang, Yufei Wang, Jiaqian Zhang, Zhangfan Wu, Xiaoyu Ji, Danfei Liu, Xiaoping Chen, Bixiang Zhang, Huifang Liang, Yiwei Li, Bifeng Liu, Shuai Wang, Xiao Xu, Yongzhan Nie, Kaichun Wu, Daiming Fan, Limin Xia
Format: Article
Language:English
Published: Wiley 2024-09-01
Series:Advanced Science
Subjects:
CCL22/CCR4
combined immunotherapy
PD‐L1
TGF‐β1/TGFβR1 signaling
Tregs
Online Access:https://doi.org/10.1002/advs.202310304
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https://doi.org/10.1002/advs.202310304

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